D.H.E.A. Sulphate (DHEAS)

The normal reference range for D.H.E.A. Sulphate (DHEAS) is DHEAS is highly age- and sex-dependent, peaking in the 20s and declining steadily thereafter, so it is read against age-specific charts. As a rough adult guide, women run about 1.0-9.5 μmol/L and men about 2.0-12 μmol/L, decreasing with age. Unlike cortisol, DHEAS is stable through the day, so timing does not matter.. Reference ranges may vary between laboratories, so always consult your healthcare provider for interpretation.

Assesses adrenal function and can indicate stress response capacity while offering insight into hormone production pathways.

High DHEAS points to excess adrenal androgen production. In women it is a common finding in polycystic ovary syndrome and can contribute to acne, excess hair growth and irregular periods. Markedly raised levels can indicate congenital adrenal hyperplasia or, less commonly, an adrenal tumour, particularly when accompanied by rapidly developing signs of virilisation. Stress can modestly raise it.

Low DHEAS is most often simply a feature of normal ageing. It can also reflect adrenal insufficiency (Addison's disease), pituitary failure (hypopituitarism), and suppression from long-term corticosteroid medication. Low DHEAS itself is rarely treated, but it can support a diagnosis of adrenal underactivity in the right clinical picture.

DHEAS is stable, so it can be drawn at any time of day without fasting. It is typically measured when investigating androgen excess in women (acne, hirsutism, irregular cycles, suspected PCOS), or as part of an adrenal work-up. It is not a routine screening test and is repeated only when clinically indicated.